By Saverio Pollice, Gilda Morlino, Michela Capuano, Tommaso Scarabino (auth.), Tommaso Scarabino (eds.)
This atlas is an in depth consultant to the imaging appearances of gliomas following remedy with neurosurgery, radiation treatment, and chemotherapy. basic and pathological findings are displayed in exact MR photographs that illustrate the capability variations as a result of remedy. specific emphasis is put on attribute appearances at the more recent useful MR imaging thoughts, together with MR spectroscopy, diffusion-weighted imaging, and perfusion imaging. those suggestions are revolutionizing neuroradiology through going past the demonstration of macroscopic changes to the depiction of previous metabolic alterations on the mobile and subcellular point, thereby permitting past and extra particular analysis. A key part comprising a few forty scientific circumstances and greater than 500 illustrations bargains a useful medical and learn software not just for neuroradiologists but additionally for neurosurgeons, radiotherapists, and scientific oncologists.
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Additional info for Imaging Gliomas After Treatment: A Case-based Atlas
For benign tumors, radical excision in most cases is the only and definitive therapy (curative surgery). Where a high risk of morbidity or mortality is associated with radical resection of the mass, it may be preferable to leave a residual tumor and undertake adjuvant therapies for its treatment (mainly RT). For malignant tumors surgery is only a part of a combined RT/chemotherapy treatment. Cytoreductive surgery is more effective the more extensive it is. In this case, the 5-year survival in low grade gliomas increases from 30% to 60%, in glioblastomas from 8 to 13 months, however, it is worse in elderly patients in whom mean survival does not exceed one year.
The extreme heterogeneity of brain tumors and moderate specificity of MR may make difficult a clear histologic diagnosis which only in typical cases is simple. In MR imaging of glioblastoma, the solid part of the tumor shows hypointense signal in T1weighted sequences and hyperintense in T2, with higher signal in areas of greater cellularity. Necrotic areas, which always appear hyperintense in T2, may be hypo-, iso- or hyperintense in T1 due to products of protein or hemoglobin degradation. Enhancement after administration of contrast medium is usually intense and irregular at the tumor margins and identifies the cellular proliferation component of the tumor.
Ology techniques with cortical activation (fMRI) enable the noninvasive evaluation of preoperative and postoperative resectability. 3. References 4. 1. Rampling R, James A, Papanastassiou V (2004) The present and future management of malignant brain tumours: surgery, radiotherapy, chemotherapy. J Neurol Neurosurg Psych 75:24-30 2. Wood JR, Green SB, Shapiro et al (1998) The prognostic 5. 6. importance of tumor size in malignant gliomas: a computed tomographic scan study by the Brain Tumor Cooperative Group.
Imaging Gliomas After Treatment: A Case-based Atlas by Saverio Pollice, Gilda Morlino, Michela Capuano, Tommaso Scarabino (auth.), Tommaso Scarabino (eds.)