Animal Models in Cardiovascular Research - download pdf or read online

By David R. Gross D.V.M., Ph.D. (auth.)

ISBN-10: 9400950063

ISBN-13: 9789400950061

ISBN-10: 9401087172

ISBN-13: 9789401087179

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4. , Anesthesia of bulls undergoing surgical manipulation of the vas deferentia. Con. J. , 39:250-255, 1975. 5. , Anesthesia - Some developments in equine practice. Proc. Am. Assoc. Equine Pract. 21st:149-l55, 1975. 6. , Introduction to Drugs Acting on the Central Nervous System. , ed. H. E. McDonald, The Iowa State University Press, Ames, Iowa, 1982. BE OPI

25 Hansters No cardiovascular data - some monkeys may require as much as 11 mg/kg. The Rhesus seems to be twice as sensitive as squirrel monkeys, on a body weight basis within 2 41 2 No data - May require 4 mg/kg for visceral pain No cardiovascular data, onset of effect 10 min 42 2 2 Increased heart rate at 5 min. post injection but back to baseline at 15, 30 and 60 min. post injected. Cardiac output increased at 5 and 15 min. but same as baseline at 30 and 60 min. No change in pulmonary artery blood gases.

However, these agents usually compete for receptor sites and have some analgesic and/or sedative properties when used alone. The list is not exhaustive but represents those agents most commonly cited as being used for cardiovascular studies in the recent literature. The effectiveness of these agents for chemical restraint, sedation and analgesia seems to be a matter of individual preference more than objective evaluation, but also involves some species variabili ty. The cardiovascular effects, dosage and appropriate comments are tabulated for each of the eleven agents in each of the species reviewed.

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Animal Models in Cardiovascular Research by David R. Gross D.V.M., Ph.D. (auth.)


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