By R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)
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Extra info for Advances in Topical Antifungal Therapy
48 The Use of Bifonazole in the First 2 Years of Life L. Muscardin, L. M. Muscardin, and L. Bonito Pediatric Hospital Bambin Gesu, Piazza S. Onofrio 4, 11265 Roma, Italy Abstract We have studied the activity of bifonazole in patients in the first 2 years of life suffering from napkin dermatitis in which Candida was verified by culture tests. The patients were chosen from children recovered in the departments of Pediatric "Bambino Gesu" Hospital Clinic and from the Outpatients Department. In five hospitalized patients the following parameters were checked before the treatment and after 3 weeks of therapy: hemochromecytometric test, glycemia, azotemia, creatininemia, bilirubinemia, GOT, GPT, LDH, ALP, ALS; the parameters did not show any change between the checks.
The average interval required for the appearance of first clinical improvement related to superficial candidosis (Fig. 2) was 5 days in the bifonazole group, 7 days in the oxiconazole group and as long as 10 days in the naftifine group. 0003) . 'vluIHlII ANOVA I 10..... ll~" II 'Jill,. ')l1I 101 rklllllm",or tlrH) 8J IpI Illlu4IfIIllltllnl rIr 11 VII III " I '0',,1111' ft' f)(M,,),! ''' U""I 111111 Ilnrl N(Jlhhrif' (I,-OO()OJ) Fig. 2. Clinical improvement of candidosis after start of treatment assessment of therapeutic results (Fig.
Bifonazole proved to be a preparation with properties contributing to patient compliance. 53 Introduction Unlike the treatment of vaginal mycoses, the treatment of dermatomycoses has the disadvantage that the majority of therapeutic agents still require application for 4 to 6 weeks or longer, depending on the agent chosen. The result of this long duration oftherapy is inadequate compliance and, in consequence, premature termination of treatment and a high rate of recurrence. In a survey among dermatologists and patients, Meinhof et al.
Advances in Topical Antifungal Therapy by R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)