By Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio Nishikimi MD, PhD (eds.)
Adrenomedullin used to be came across in 1993 in an extract of human pheochromocytoma whereas tracking cAMP degrees in rat platelets. Adrenomedullin has attracted massive curiosity between cardiologists because of its influence at the cardiovascular approach which incorporates a lessen in blood strain in vivo; an impression on vascular gentle muscle cells; raises cAMP degrees; not directly reduces blood strain and has a job within the pathogenesis of arteriosclerosis.
Adrenomedullin in heart problems is an up to date overview of the main appropriate points of adrenomedullin. It features a extensive variety of fields together with biochemistry, molecular biology, body structure, pharmacology, pathophysiology of heart problems and scientific functions of adrenomedullin to cardiovascular disease.
Toshio Nishikimi, MD, PhD, is an affiliate Professor within the division of high blood pressure and Cardiorenal drugs, Dokkyo college tuition of medication, Tochigi, Japan.
Read Online or Download Adrenomedullin in Cardiovascular Disease PDF
Best cardiovascular books
It is a 3-in-1 reference ebook. It supplies an entire clinical dictionary overlaying hundreds of thousands of phrases and expressions in relation to atherosclerosis. It additionally offers broad lists of bibliographic citations. ultimately, it presents details to clients on find out how to replace their wisdom utilizing quite a few net assets.
"Das Herzkatheterlabor" kombiniert theoretisches und praktisches Basiswissen f? r das kardiologische Assistenzpersonal im Herzkatheterlabor und f? r alle in der Kardiologie t? tigen Personen. ? bersichtlich und mit zahlreichen Abbildungen zeigt die Autorin das gesamte Spektrum an diagnostischen und interventionellen Eingriffen in einem Herzkatheter-labor auf.
Sitting an accreditation exam is a frightening prospect for plenty of trainee echocardiographers. And with an expanding force for the accreditation of echocardiography laboratories and person echocardiographers, there's a want for an all-encompassing revision relief for these looking accreditation.
Chance elements for Cerebrovascular sickness and Stroke handle the connection of a large choice of vascular chance elements within the spectrum of cerebrovascular ailments. a world team of execs the leading edge of study and schooling, offer their services approximately environmental and genetic determinants for cerebrovascular disorder and stroke.
- Clinical Cardiac Electrophysiology in the Young (Developments in Cardiovascular Medicine)
- Clinical Trials in Heart Disease: A Companion to Braunwald's Heart Disease
- 2003 European Society of Hypertension - European Society of Cardiology Guidelines for the Management of Arterial Hypertension
- Complications During Percutaneous Interventions for Congenital and Structural Heart Disease
- Diabetes and Cardiovascular Disease: Etiology, Treatment, and Outcomes
Additional info for Adrenomedullin in Cardiovascular Disease
1995) A human orphan calcitonin receptor-like structure. Biochem Biophys Res Commun 206:341-347. Fukai N, Shichiri M, Ozawa N, Matsushita M, and Hirata Y (2003) Coexpression of calcitonin receptor-like receptor and receptor activity-modifying protein 2 or 3 mediates the antimigratory effect of adrenomedullin. Endocrinology 144:447453. Gether U. (2000) Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr Rev 21:90-113. Hall JM, Siney L, Lippton H, Flyman A, Kang-Chang J, and Brain SD.
Circulation 105:106-111. Shindo T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A, Kuwaki T, Ju KH, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y, Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata Y, and Kurihara H. (2001) Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation 104:1964-1971. Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T, and Matsuo H. (1995) Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells.
2002). , 1995). Since NO activates soluble guanylate cyclase to increase intracellular cGMP 31 levels in VSMC, cGMP-dependent protein kinase (PKG) could function as a major signaling molecule for AM-induced vasorelaxation. 8. , 2001). , 2004). , 2003). These data are consistent with the notion that PI3 kinase/AKT pathway plays a pivotal role in certain biological actions by AM, although further studies are required to elucidate how the PI3 kinase is activated following AM stimulation. 9. UNKNOWN SIGNAL TRANSDUCTION PATHWAY(S) FOR APOPTOSIS AND MIGRATION (1) ANTI-APOPTOTIC EFFECT After serum-deprivation, endothelial cells undergo apoptosis.
Adrenomedullin in Cardiovascular Disease by Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio Nishikimi MD, PhD (eds.)