Adrenomedullin in Cardiovascular Disease - download pdf or read online

By Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio Nishikimi MD, PhD (eds.)

ISBN-10: 0387254048

ISBN-13: 9780387254043

ISBN-10: 0387254056

ISBN-13: 9780387254050

Adrenomedullin used to be came across in 1993 in an extract of human pheochromocytoma whereas tracking cAMP degrees in rat platelets. Adrenomedullin has attracted massive curiosity between cardiologists because of its influence at the cardiovascular approach which incorporates a lessen in blood strain in vivo; an impression on vascular gentle muscle cells; raises cAMP degrees; not directly reduces blood strain and has a job within the pathogenesis of arteriosclerosis.

Adrenomedullin in heart problems is an up to date overview of the main appropriate points of adrenomedullin. It features a extensive variety of fields together with biochemistry, molecular biology, body structure, pharmacology, pathophysiology of heart problems and scientific functions of adrenomedullin to cardiovascular disease.

Toshio Nishikimi, MD, PhD, is an affiliate Professor within the division of high blood pressure and Cardiorenal drugs, Dokkyo college tuition of medication, Tochigi, Japan.

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Circulation 105:106-111. Shindo T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A, Kuwaki T, Ju KH, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y, Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata Y, and Kurihara H. (2001) Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation 104:1964-1971. Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T, and Matsuo H. (1995) Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells.

2002). , 1995). Since NO activates soluble guanylate cyclase to increase intracellular cGMP 31 levels in VSMC, cGMP-dependent protein kinase (PKG) could function as a major signaling molecule for AM-induced vasorelaxation. 8. , 2001). , 2004). , 2003). These data are consistent with the notion that PI3 kinase/AKT pathway plays a pivotal role in certain biological actions by AM, although further studies are required to elucidate how the PI3 kinase is activated following AM stimulation. 9. UNKNOWN SIGNAL TRANSDUCTION PATHWAY(S) FOR APOPTOSIS AND MIGRATION (1) ANTI-APOPTOTIC EFFECT After serum-deprivation, endothelial cells undergo apoptosis.

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Adrenomedullin in Cardiovascular Disease by Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio Nishikimi MD, PhD (eds.)

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