By David T. Curiel (Editor), Joanne T. Douglas (Editor)
Adenoviral Vectors for Gene treatment offers exact and entire assurance of those very important healing brokers. the subjects lined during this publication variety from the fundamental biology of adenoviruses, during the building and purification of adenoviral vectors, state-of-the-art vectorology and using adenoviral vectors in preclinical animal types, to regulatory concerns which needs to be thought of ahead of the initiation of human medical gene treatment trials. The large scope of this precise quantity offers the reader with an entire knowing of the improvement and use of adenoviral vectors. Key positive factors* presents entire assurance of simple biology of adenoviruses, in addition to the development, propagation and purification of adenoviral vectors* Introduces universal ideas for the advance of adenoviral vectors besides state-of-the-art equipment for his or her development* Demonstrates noninvasive imaging of adenovirus-mediated gene move* Discusses application of adenoviral vectors in animal illness versions* Considers Federal Drug management laws for human medical trials
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Additional resources for Adenoviral Vectors for Gene Therapy
1995). Adenovirus fiber. Curr. Top. Microbiol. Immunol. 199, 163-200. 32. Stewart, P. , Gary, R. , Peterson, S. , and Ghiu, C. Y. (2000). Digitally collected cryoelectron micrographs for single particle reconstruction. Microsc. Res. Tech. 49, 224-232. 33. Von Seggern, D. , Ghiu, G. , Fleck, S. , Stewart, P. , and Nemerow, G. R. (1999). /. Virol. 73, 1601-1608. 34. Stewart, P. , Ghiu, G. , and Nemerow, G. R. (1997). Gryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization.
Cryo-EM reconstructions of the Ad3 penton dodecahedron both with and without the fiber reveal a subtle shift of the RGD protrusions outward by ^^15 A when the fiber is present, but no open hole in the fiberless complex . A similar observation was made for an Ad5 vector both with and without the fiber . These results indicate a subtle conformational change of the penton base during fiber binding and possible expansion of the penton base to allow insertion of the N-terminal end of the fiber.
Fleck, S. , Stewart, P. , and Nemerow, G. R. (1999). /. Virol. 73, 1601-1608. 34. Stewart, P. , Ghiu, G. , and Nemerow, G. R. (1997). Gryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization. EMBO J. 16, 1189-1198. 35. Gepko, G. , and Sharp, P. A. (1982). Assembly of adenovirus major capsid protein is mediated by a nonvirion protein. Cell 31, 407-415. 36. , and Schnurr, D. P. (1996). /. Virol. 70, 1836-1844. 37. , and Philipson, L. (1980). Limited proteolysis and a reactive cysteine residue define accessible regions in the native conformation of the adenovirus hexon protein.
Adenoviral Vectors for Gene Therapy by David T. Curiel (Editor), Joanne T. Douglas (Editor)