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Hur, S. M. Marcus, D. K. Bhaumik, J. A. Erkens, R. M. Herings, and J. J. Mann. 2007. Early evidence on the effects of regulators’ suicidality warnings on SSRI prescriptions and suicide in children and adolescents. Am J Psychiatry 164(9):1356–1363. , and K. Jamison. 2007. Manic-depressive illness: Biopolar disorders and recurrent depression. 2nd ed. Oxford, UK: Oxford University Press. Greenhouse, J. , E. E. Kaizar, K. Kelleher, H. Seltman, and W. Gardner. 2008. Generalizing from clinical trial data: A case study.

Html DATA COLLECTION AND OPTIMIZATION 23 For three decades we have known that low serotonin levels are associated with suicidality (Mann, 2003). The deficiency is so consistent across studies that Mann describes low serotonin as a long-standing trait. The method used to obtain these findings was by pharmacological challenge with the amphetamine derivative fenfluramine. Upon fenfluramine challenge, serotonin levels should normally rise. In suicidal groups, however, serotonin levels do not rise as highly as they do in control groups.

Through the creation of its Critical Path Initiative,1 the FDA has taken unprecedented steps to forge partnerships with the National Institutes of Health (NIH), industry, advocacy groups, and scientific societies, among others. Under the auspices of the Critical Path Initiative, the FDA is committed to promoting development of the infrastructure and furnishing tools to make product development more efficient and streamlined. It hopes to help sponsors predict early in the development process which products are most likely to be safe and effective, thereby avoiding expensive product failures in the later stages of development.

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A 3/4-Approximation Algorithm for Multiple Subset Sum by Caprara A.

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